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Preliminary Scientific Program |
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SUNDAY, DECEMBER 2, 2007 |
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| 15:00-18:00 | Registration | |
| 16.00-18.00 | Workshop: European trials/research proposals | |
MONDAY, DECEMBER 3, 2007 |
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| 09:00 | Welcome/introduction O.F.W. James, UK |
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| Clinical disease | ||
| Chairs: | R. Poupon, France O.F.W. James, UK |
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| 09:10 | Natural history: (including HCC, transplantation, recurrence) J. Neuberger, UK |
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| 09:40 | Fatigue and Quality of life D.E.J. Jones, UK |
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| 10:10 | Osteoporosis A. Pares, Spain |
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| 10:25 | Overlap syndromes A. Lohse, Germany |
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| 10:40 | Discussion | |
| 10:55 | Coffee Break | |
| Biogeography | ||
| Chairs: | J. Neuberger, UK M.E. Gershwin, USA |
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| 11:20 | Epidemiology & disease clustering O.F.W. James, UK |
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| 11:50 | Women M. Podda, Italy |
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| 12:05 | Molecular epidemiology: MHC genetics P.T. Donaldson, UK |
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| 12:20 | Molecular epidemiology: Non-MHC genetics A. Floreani, Italy |
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| 12:35 | Discussion | |
| 12:50 | Lunch Break | |
| Pathophysiology I | ||
| Chairs: | A.D Burt, UK D.H. Adams, UK |
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| Target-cell biology | ||
| 13:45 | Biliary epithelial cell M. Strazzabosco, USA |
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| 14:15 | Molecular mechanisms of cholestasis M. Trauner, Austria |
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| 14:40 | Cholangiocyte anion exchange J.M. Prieto, Spain |
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| 15:00 | Bile acids and other lipids F. Kuipers, The Netherlands |
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| 15:20 | Estrogens and Cholangiocytes D. Alvaro, Italy |
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| 15:40 | Discussion | |
| 16:00 | Coffee Break | |
| Pathophysiology II | ||
| Chairs: |
M. Pinzani, Italy J-F. Dufour, Switzerland |
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| 16:25 | PBC – the value of histological grading systems A.D. Burt, UK |
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| 16:45 | Biliary fibrosis C. Housset, France |
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| 17:15 | The hepatic transcriptome in PBC G. McCaughan, Australia |
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| 17:45 | Retroviruses and PBC pathogenesis A. Mason, Canada |
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| 18:00 | Discussion | |
| 20:00 | Welcome Reception/Dinner | |
TUESDAY, DECEMBER 4, 2007 |
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| Autoimmunity I | ||
| Chairs: | D.E.J. Jones, UK R.L. Coppel, Australia |
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| 08:45 | Lymphocyte recruitment to the biliary epithelium in PBC D.H. Adams, UK |
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| 09:15 | Th17 cells and autoimmunity M. Veldhoen, UK |
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| 09:35 | PBC-specific AMA: overview M.F. Bassendine, UK |
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| 09:55 | Role of lipoic acid J.M. Palmer, UK |
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| 10:10 | PBC-specific ANA P. Invernizzi, Italy |
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| 10:25 | Discussion | |
| 10:40 | Coffee Break | |
| Autoimmunity II | ||
| Chairs: | A. Lohse, Germany P. Invernizzi, Italy |
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| 11:00 | Triggers: Xenobiotics, Infections & TLR ligands E.M. Gershwin, USA |
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| 11:45 | Cellular immune response in PBC H. Kita, Japan |
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| 12:05 | Overview of experimental models R.L. Coppell, Australia |
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| 12:30 | Discussion | |
| 12:45 | Lunch Break | |
| Therapeutics I | ||
| Chairs: | M. Podda, Italy A. Pares, Spain |
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| 13:45 | Lessons from trials in PBC E.J. Heathcote, Canada |
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| 14:00 | Targeting cholestasis R. Poupon, France |
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| 14:25 | Targeting inflammation H. Rautiainen, Finland |
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| 14:40 | Targeting itch U. Beuers, The Netherlands |
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| 14:55 | Discussion | |
| 15:10 | Coffee Break | |
| Therapeutics II | ||
| Chairs: | M.F. Bassendine, UK U. Beuers, The Netherlands |
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| 15:40 | Targeting hypercholesterolaemia J-F. Dufour, Switzerland |
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| 15:55 | Targeting fatigue J.L. Newton, UK |
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| 16:10 | Targeting fibrosis M. Pinzani, Italy |
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| 16:25 | Wither trials? K. Lindor, USA |
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| 16:45 | Discussion | |
| 16:55 | Conclusion: Priorities for the next decade R. Poupon, France |
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| 17:10 | Farewell M.F. Bassendine, UK |
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